HPE ProLiant ML350 Gen10 Server

Executive Overview

The HPE ProLiant ML350 Gen10 Server is a secure dual-socket tower server that delivers high performance, expandability, and proven reliability for growing SMBs, remote/branch offices, and enterprise data centers. Designed with a rackable 5U chassis, it supports up to two Intel® Xeon® Scalable processors, 3.0 TB of DDR4 memory, extensive drive storage choices, and multi-GPU expansion.

Technical Specifications Summary

Feature	Specification Details
Form Factor	4U / 5U Tower (Rack-convertible with optional 5U Rack Mount Kit)
Processor Sockets	2 Sockets (LGA 3647)
Processor Family	1st & 2nd Generation Intel® Xeon® Scalable Processors (Bronze, Silver, Gold, Platinum)
Maximum Cores	Up to 28 cores per processor (Up to 56 cores per system)
Memory Slots	24 DIMM slots (12 DIMM slots per processor)
Maximum Memory	Up to 3.0 TB using 128 GB DDR4 LRDIMMs
Memory Speed	Up to 2933 MT/s (2nd Gen Xeon) / 2666 MT/s (1st Gen Xeon)
Drive Bays Supported	• Up to 24 SFF SAS/SATA HDD/SSD • Up to 16 SFF SAS/SATA + 8 SFF NVMe PCIe SSDs • Up to 12 LFF SAS/SATA (Hot-Plug or Non-Hot-Plug)
Storage Controllers	• Embedded: HPE Smart Array S100i SR Gen10 Software RAID • Essential/Performance: HPE Smart Array E208i-a / P408i-a / P408i-p / P816i-a / P824i-p
PCIe Expansion Slots	Up to 8 PCIe 3.0 slots (4 slots standard on CPU1, 4 slots enabled with CPU2)
GPU Acceleration	Supports up to 4 double-wide or 8 single-wide GPUs (e.g., NVIDIA T4, RTX series)
Embedded Networking	HPE Ethernet 1Gb 4-port 369i Adapter (4 x RJ-45)
Management Architecture	HPE iLO 5 (Integrated Lights-Out) with Security Root of Trust
Power Supply Options	HPE Flexible Slot Redundant Power Supplies: 500W, 800W, 1600W (80 PLUS Platinum/Titanium)
Cooling System	Standard 2 system fans; optional Redundant Fan Kit (4 additional fans, hot-plug, N+1)

Detailed Hardware Breakdown

1. Processor Architecture

• Supported Families:

  • 2nd Gen Intel® Xeon® Scalable Processors: 8200, 6200, 5200, 4200, 3200 Series

  • 1st Gen Intel® Xeon® Scalable Processors: 8100, 6100, 5100, 4100, 3100 Series

• Max Thermal Design Power (TDP): Up to 205W per socket

• UPI Speed: Up to 10.4 GT/s per link (3 UPI links)

2. Memory Architecture

• Type: HPE DDR4 SmartMemory (RDIMM / LRDIMM)

• Channels: 6 memory channels per processor, 2 DIMMs per channel (24 DIMMs total)

• Advanced Memory Protection: Advanced ECC, Online Spare Mode, Memory Lockstep Mode, Fast Fault Tolerance

3. Storage & Drives

• Drive Backplane Options:

  • 8 SFF Chassis: Expandable to 16 SFF or 24 SFF SAS/SATA drives.

  • NVMe Option: Up to 8 SFF NVMe PCIe SSDs in Box 2 (requires NVMe Riser Kit).

  • 4 LFF Chassis: Expandable to 8 LFF or 12 LFF SAS/SATA drives (Hot-Plug or Non-Hot-Plug).

• Max Internal Capacity: Up to 192 TB using 12 x 16 TB LFF drives.

• Optical Drives: Optional Slim-line ODD Bay Kit (DVD-ROM / DVD-RW).

4. PCIe Expansion & GPU Support

• Slot Configuration:

  • Slot 1 (CPU1): PCIe 3.0 x16 (Full-height, Full-length)

  • Slot 2 (CPU1): PCIe 3.0 x8 (Full-height, Half-length)

  • Slot 3 (CPU1): PCIe 3.0 x16 (Full-height, Full-length)

  • Slot 4 (CPU1): PCIe 3.0 x8 (Full-height, Half-length)

  • Slots 5–8 (Requires CPU2): PCIe 3.0 (Slots 5 & 7 x16; Slots 6 & 8 x8)

• GPU Acceleration: Dedicated support for NVIDIA Quadro RTX4000/6000/8000, Tesla T4, and P4000 cards.

5. Management & Security

• Embedded Management: HPE iLO 5 Standard (Integrated Lights-Out) with Intelligent Provisioning.

• Management Software: HPE OneView Standard / Advanced, HPE iLO Amplifier Pack, HPE InfoSight.

• Security Features:

  • Silicon Root of Trust (Immutable hardware validation)

  • TPM 2.0 (Trusted Platform Module) support

  • Chassis Intrusion Detection Switch

  • Secure Boot & Secure Start

  • Server Configuration Lock & One Button Secure Erase

6. External Connectivity & Ports

• Video/Graphics: 1 x VGA Port, 1 x DisplayPort (Rear)

• Network Interface: 4 x 1GbE RJ-45 ports + 1 x Dedicated iLO Management RJ-45 port

• USB Ports: 6 x USB 3.0 (2 Front, 2 Rear, 2 Internal)

• Serial Port: 1 x Serial Port (Rear)

7. Physical Specifications

• Dimensions (Tower): 46.25 cm (H) x 17.4 cm (W) x 64.8 cm (D) / (18.2 in x 6.85 in x 25.51 in)

• Weight: ~21.0 kg (45.0 lb) minimum; ~42.0 kg (92.0 lb) fully loaded

• Warranty: 3/3/3 Warranty (3 years Parts, 3 years Labor, 3 years Onsite Support)